What is Pluronic F127 used for?
Pluronic F-127 has been widely used in drug delivery, controlled release, and MSC encapsulation applications [34]. The thermosensitive properties of Pluronic F-127 make it an attractive biomaterial for regenerative applications in dentistry or medicine.
Is Pluronic F127 toxic?
Pluronic F-127 (i.e., poloxamer) is water soluble and exhibits low toxicity30.
How do you prepare Pluronic F127?
1. Dissolve 1 g of Pluronic® F-127 in 10 mL distilled water to make a 10% (w/v) stock solution, or 2 g of Pluronic® F-127 in 10 mL of anhydrous dimethyl sulfoxide (DMSO) to make a 20% (w/v) stock solution. These may require heating from 40 to 50 °C for about 30 minutes. Store solution at room temperature.
Is Pluronic a surfactant?
Gibco® Pluronic® F-68 is a non-ionic surfactant used to control shear forces in suspension cultures. Pluronic® F-68 can also be used to reduce foaming in stirred cultures and reduce cell attachment to glass.
Is Pluronic F127 hydrophobic?
Pluronic F127 is an amphiphilic block copolymer of PEG-PPG-PEG structure (PEG: poly(ethylene glycol); PPG: poly(propylene glycol)). The central PPG block becomes hydrophobic, while the PEG blocks remain hydrophilic and above a critical temperature, self-aggregating into micelles.
What is Pluronic F108?
Pluronic® F108 is a tri block copolymer and a terminal primary dihydroxy-functional oligomer. It behaves as a nonionic surfactant. It is a surface active material whose properties are dependent on the hydrophilic (EO)/hydrophobic (PO) ratio. High EO content gives better o/w stabilizers.
Is Pluronic FDA approved?
They are also known as poloxamers and are non-toxic, biodegradable and FDA approved [22]. Because of these features, the binary systems Pluronic F127/water have been used in clinical applications such as drug and gene delivery [32] and cell separation [33].
Is Pluronic F127 soluble in water?
Pluronic® F-127 is a nonionic detergent useful for solubilizing hydrophobic dye molecules such as cell-permeable AM esters of Fura-2, Fluo-3, Indo-1, or Rhod-2 calcium indicators to facilitate cell loading. Pluronic® F-127 is usually dissolved in water or DMSO with gentle heating.
What is Pluronic gel?
Description: Clear gel at room temperature, Pluronic Gel 30% is used in combination with Lipmax to form a PLO Gel for higher concentrations of actives ingredients (>=10%). Targeted malleability is obtained when stored between 2-8°C.
What is poloxamer 407 used for?
Poloxamer 407 has been used as a detergent, surfactant, and stabilizer. It facilitates the solubilization of hydrophobic molecules, promoting their rapid and complete dissolution in polar media [6,47].