When do you draw trough levels for gentamicin?
The trough sample is drawn immediately prior to the next dose. Peak samples should be drawn 45 to 60 minutes after an IM injection, 30 minutes after the end of a 30-minute IV infusion, or immediately after a 60-minute IV infusion.
What is the therapeutic range for gentamicin?
Gentamicin has a narrow therapeutic range in serum of 5 to 10 mg/l (10.5 to 20.9 µmol/l) for peak levels and 1 to 2 mg/l (2.1 to 4.2 µmol/l) for trough levels.
When do I give gentamicin levels?
Gentamicin levels should be taken 6-14 hours after the start of the infusion. For a daily dose of 5mg/kg/day the Urban-Craig nomogram can be used. Gentamicin levels should be taken 8-12 hours after the dose.
When should trough levels be drawn?
The trough level is the lowest concentration in the patient’s bloodstream, therefore, the specimen should be collected just prior to administration of the drug. The peak level is the highest concentration of a drug in the patient’s bloodstream.
What should Vanco trough be?
The reference range for vancomycin trough levels is 5-15 mcg/mL. The reference range for vancomycin peak levels is 20-40 mcg/mL.
Why is gentamicin not given orally?
Aminoglycosides such as gentamicin cannot be administered orally for treatment of systemic infection because they are not absorbed from the intact gastrointestinal tract [294].
What is a normal Vanco trough level?
Why do we do gentamicin levels?
Serum levels are monitored to reduce the risk of significant accumulation and nephrotoxicity. Dose is adjusted according to age and renal function.
What happens when vancomycin trough is high?
If the dose is too high, excessive concentrations of vancomycin can result in serious side effects, including hearing loss (ototoxicity) and kidney damage (nephrotoxicity). The goal is to find a dose for vancomycin that is both safe and effective.
What do you do when Vanco trough is high?
If the high trough level appears genuine, use the vancomycin dose adjustment calculator to obtain a new dosage regime. Consider omitting dose based on the level: – If vancomycin trough level is 20-25mg/L, give new dosage regime without omitting any doses. Take a level before the 4th new dose.
When to check gentamicin trough?
Pre-dose (trough) gentamicin levels should be checked after 24 hours and then twice weekly (target <1mg/L). Peak gentamicin levels, taken one hour after administration, can also be measured (target 3–5mg/L). Individualised dosing based on the patient’s pharmacokinetics can also be used.
When to draw gentamicin trough?
The trough sample is drawn immediately prior to the next dose. Peak samples should be drawn 45 to 60 minutes after an IM injection , 30 minutes after the end of a 30-minute IV infusion , or immediately after a 60-minute IV infusion.
How often are gentamicin troughs?
The most commonly used dose is 80mg three times daily. Pre-dose (trough) gentamicin levels should be checked after 24 hours of treatment (target <2mg/L) and peak levels measured one hour post-dose (target 5–10mg/L). Some infections, such as Pseudomonas spp.may require an increased dose to achieve higher peak levels.
What is Gent trough?
The Gentamicin Trough Level Blood Test is a test to identify the trough levels of gentamicin. It is used to calculate and determine the necessary amounts of gentamicin to be administered, the timing of the administration, and to ensure that gentamicin levels stay within a safe yet effective range.