What does HCV genotype 3 mean?
Within the 6 major clinical HCV genotypes, genotype 3 represents 22–30% of all infection, and is described as a unique entity with higher rates of steatosis, faster progression to cirrhosis, and higher rates of hepatocellular carcinoma.
What is a good HCV ratio?
A single negative hepatitis C virus (HCV) RNA test result together with a reactive HCV antibody screen result with a signal-to-cutoff ratio of 8.0 or greater does not rule out the possibility of chronic HCV infection. Repeat testing for HCV RNA in 1 to 2 months is recommended in patient at risk for chronic hepatitis C.
What is the genome size of HCV virus?
The HCV genome, which is approximately 9600 nucleotides (nt) long, contains two short untranslated regions at each end (5’UTR and 3’UTR) along with a single open reading frame encoding three structural (core, E1, and E2) and seven non-structural (p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B) proteins.
What is a high level for hep C?
A viral load of more than 800,000 IU/mL is considered high. This can make successful treatment more challenging. Undetectable viral load. A viral load of less than 615 IU/mL means there’s no detectable HCV, or it’s too low to detect.
What is the structure of the HCV genome?
The HCV genome contains a single, long, open reading frame (3,006-3037 codons) flanked by 5′ and 3′ untranslated regions (UTRs). The HCV RNA genome is used both for translation and transcription.
How many people have HCV genotype 3 infection?
In the United States, among all persons living with hepatitis C virus (HCV) infection, approximately 10% have HCV genotype 3 infection, with an even higher proportion of HCV genotype 3 among persons who inject drugs.
What do you need to know about hepatitis C genotype 3?
Hepatitis C Genotype 3: What You Should Know. Medically reviewed by Stacy Sampson, DO, specialty in Family Medicine, on January 25, 2019 — Written by Annette McDermott. Hepatitis C is a contagious viral disease that may damage your liver. It’s caused by the hepatitis C virus (HCV).
How big is the 3’x region in HCV?
The 3′ region is approximately 225 nucleotides long and it consists of three components: variable, a long poly (U/UC) tract, and 3’X region. The 3’X region serves as a key factor in switching between translation and RNA transcription of the HCV RNA.